Impact Projects and Publications

At the heart of the UF Pepper Center lies a deep-seated dedication to unraveling the complexities of mobility loss.

Gray haired man eating an apple

how humans age

We connect the dots in unexpected ways, to reveal not just how we age, but how we can age with grace and autonomy.  By leveraging the latest scientific tools and uniquely crafted research designs, our objective is to discover risk factors, understand the biology of aging and ultimately develop treatment strategies to preserve and restore mobility function.

Our impact is characterized by our published science and the projects we lead. We also build partnerships with our local community organizations to deliver our research findings and their implications on preserving mobility and general health in late life. Here you will find our historical research footprint through past projects and publications. You will also learn about what new projects are being implemented and how to contribute to our mission by volunteering for research.  

High Impact Journal Articles

Listed below are publications that have received the most media attention and citations from 2020-2024.

Cover of Nature with mouse in wheel
The cover of Nature for May 2, 2024 featured an article by our researchers (see MoTrPAC Study Group's "Temporal dynamics of the multi-omic response to endurance exercise training.")

Bernabei R, Landi F, Calvani R, et al. Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project). Bmj. 2022;377:e068788. doi:10.1136/bmj-2021-068788

Bhasin S, Travison TG, Manini TM, et al. Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium. Journal of the American Geriatrics Society. 2020;68(7):1410-1418. doi:10.1111/jgs.16372

Fielding RA, Atkinson EJ, Aversa Z, et al. Biomarkers of Cellular Senescence Predict the Onset of Mobility Disability and Are Reduced by Physical Activity in Older Adults. The Journals of Gerontology: Series A. 2023;79(3):glad257. doi:10.1093/gerona/glad257

McDermott MM, Spring B, Tian L, et al. Effect of Low-Intensity vs High-Intensity Home-Based Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease. Jama. 2021;325(13):1266-1276. doi:10.1001/jama.2021.2536

MoTrPAC Study Group; Lead Analysts; MoTrPAC Study Group. Temporal dynamics of the multi-omic response to endurance exercise training. Nature. 2024 May;629(8010):174-183. doi: 10.1038/s41586-023-06877-w. Epub 2024 May 1. PMID: 38693412; PMCID: PMC11062907.

Pahor M, Guralnik JM, Anton SD, et al. Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability. Journal of the American Geriatrics Society. 2020;68(4):872-881. doi:10.1111/jgs.16365

Please contact us if you have any trouble accessing these publications. Many are freely available through the PubMed online portal from the NIH’s National Library of Medicine. To see evidence of our connection to a particular article, look for the section on Grants and/or Funding Sources.